Biological systems can remain unaltered for long periods. Yet to survive in fluctuating environments they must also undergo rapid diversification. However, mechanisms that safeguard the fidelity of replication often limit the source of such novelty to relatively modest changes in DNA sequence. My laboratory’s primary focus is to achieve a molecular understanding of this paradox, which offers the potential to thwart human pathologies ranging from cancer to neurodegeneration.
Stanford University School of Medicine
Clark Center W350
318 Campus Drive
Stanford, CA 94305